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In recent years, 3D genome configuration has emerged as an important regulator of transcriptional control and cellular identity (Taddei et al., 2004 [4]; Lanctot et al., 2007 [5]; Gibcus and Dekker, 2013; Misteli, 2009 [7]).
(A) Genome configuration of the p53 knockout allele in parental p53+/− hESCs.
All trees confirm the StStHH genome configuration of the Elymus species.
Secondly, the genome configuration changed from a linear to a circular molecule.
In general, bioinformatic and experimental studies suggest that genome configuration and copy-number or the protection and repair functions of sensitive bacteria do not have unique properties that predispose them to DNA damage or inefficient DNA repair [5], [20], [21].
Our results clearly confirm these studies, but we considered the StStHH genome configuration to be well-established before the start of the study, rather than a hypothesis in need of additional tests.
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In the case of Vigna, accurate estimation of the relative levels of minor genome configurations will require sequencing the genome to a depth of perhaps 1000 10,000×.
Inexpensive, high-throughput sequencing technologies have the potential to produce deep enough coverage to quantify the relative in vivo proportions of dominant and low-level recombinant mitochondrial genome configurations throughout the genome.
While this approach has led to the discovery of many imprinted genes, and to the refinement of phenotypic analysis of the consequences of disruptions in imprinting, not all genomic regions are covered by uniparental disomies, and there is a risk that such aberrant genome configurations may distort expression patterns.
We report here the finding of two alternative genome configurations in ssp.
In contrast, our probing of plastid genome structure in M. truncatula revealed two stable plastid genome configurations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com