Sentence examples for genome concepts from inspiring English sources

Despite all of these issues, the pan and core genome concepts have merit, even if their estimation is problematic.

In that sense, the core and pan genome concepts begin to address both conceptual problems (e.g., what is a bacterial species?) and applied problems (e.g., how likely is it that an individual of a given bacterial species is a pathogen?).

The core and pan genome concepts have been proposed as a way to characterize the distribution of gene families within a group of organisms, e.g., within a species or genus [ 5, 6, 16, 18, 20- 22].

Extreme variation in estimates of core and pan genome sizes makes it difficult to utilize these measures to quantify or compare the degree of acquisition and loss of gene families within a particular group or to make meaningful biological interpretations of the core and pan genome concepts.

This question was addressed in the landmark publication in 2002 that introduced the "druggable genome" concept [1].

While the use of the core genome concept has led to important insights into the evolution of bacterial species and identification of potentially important novel genes, there has been little discussion regarding actual expression of the core genome genes as proteins and the extent of this expression across the set of bacteria under study.

All of these characteristics are to be expected in light of the core genome concept.

The dGene program is an updated version of the druggable genome concept introduced in 2002 by Hopkins and Groom [ 37].

However, the degree to which the core genome concept can be widely applied across all bacteria may well depend on factors such as the relative ease with which the species is naturally transformable, as well as the existence and specificity of restriction modification systems.

For this reason, the pan-genome concept has triggered new investigations on genomic diversity for several bacterial species, including Streptococcus spp. [ 24, 28, 29], Haemophilus influenzae [ 25], Neisseria meningitides [ 30], Escherichia coli [ 31- 33], and Lactococcus lactis [ 34].

In order to describe these large genetic reservoirs the pan-genome concept was introduced [ 1].