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For example, Peart et al. (2005) found >40% of all genes on the genome changing at a 5% FDR.
Importantly, the fractions of the genome changing after 120 min in the wild-type strain were 5.4% up and 11% down.
For example, St Laurent et al. have shown that there are thousands of intronic RNAs in the mouse genome changing throughout the inflammation time course that are likely to be functional [ 39].
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That family tree shows that some regions of the rhinovirus genome are changing all the time but that others never change.
Epigenetic modifications are chemical changes that occur within a genome without changing the DNA sequence.
DNA methylation is associated with histone modifications and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture.
This massively parallel intervention, as the changes are known, is one of the advances that would be needed in another project Dr. Church and others have contemplated, that of recreating the mammoth by starting with an elephant's genome and changing it at the 400,000 sites at which elephant DNA differs from that of the mammoth.
Gire, Sabeti, and their colleagues found that in the current outbreak the virus's genome is changing fairly quickly, including in regions that are key for the accuracy of the PCR-based diagnostic tests.
Epigenetics refers to events that modulate activity of the genome without changing its sequence.
In comparison, the epigenome, as first defined by Waddington (1942), refers to chemical modifications that occur within a genome without changing the DNA sequence (Holliday 2006; Murrell et al. 2005; Waddington 1942).
Although intron-associated ORFs, in particular those encoding HEs, have a great potential to insert copies in different locations within the genome, thereby changing gene order, we did not observe a strong correlation with gene rearrangements.
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