Sentence examples for genome altered from inspiring English sources
In agreement with the genomic analyses of tumors, FGFR3 mutant lines showed lower genomic instability (genome altered: 1024 ± 461 Mb vs. 1402 ± 349 M, P = 0.06, Wilcoxon).
DNA was extracted from 42 fresh frozen TaG2 UC with minimal genomic alteration (<2% genome altered by aCGH; Platt et al, manuscript in preparation) and 45 bladder cell lines using QIAamp DNA kit (Qiagen).
By contrast, TP53 mutant lines showed higher genomic instability (genome altered: 1381 ± 366 Mb vs. 1023 ± 433 Mb, P = 0.04) (Additional file 2: Figure S1 and Additional file 1: Table S4).
Similar tendencies were observed when using 3 different metrics to assess genomic instability (total size of the genome altered, fraction of probes altered, or number of altered segments identified; see methods section).
We verified if genomic instability as measured by proportion genome altered (PGA) could have prognostic value in ER + breast cancers from the METABRIC cohort [ 4].
To gain a more accurate assessment of the relationship of STAG2 mutation with genomic instability, we tested the relationship of mutation with genome-wide copy number alterations measured as fraction of genome altered (FGA; percentage of clones on the array that reported significantly altered copy number).
During embryonic development, specific regions of the genome alter their chromatin organization [ 1].
The CRISPR/Cas system holds the potential to knockout specific regions of the genome, alter multiple loci simultaneously, and selectively manipulate gene expression over time.
Copy number variation (CNV): a segment of DNA (>1 kb) that is present at a variable copy number compared to the reference genome, altering the diploid status at a particular locus.
Although 58% of all homozygous mis-sense variants in the 12 genomes alter conserved sites in all three assessments, almost 40% of these (183/463) are predicted to be functionally neutral by all six programs.
It is possible that RSV promoter activity within the virus genome alters the activity of viral promoters.
