Sentence examples for genome activation from inspiring English sources

This includes the major regulator of zygotic genome activation smaug, and the cognate activating kinase pan gu (Additional file 1).

Prior to zygotic genome activation, the genome is mostly unstructured.

The establishment of the TAD structure requires DNA replication but not zygotic genome activation.

To compare the oocyte versus the blastocyst transcriptome and provide data on molecular pathways before and after embryonic genome activation.

Interestingly, the DHSs with OCT4 binding motifs are enriched at the timing of zygotic genome activation (ZGA) in humans, but not in mice.

UTR-seq revealed two temporal degradation programs: a maternally encoded early-onset program and a late-onset program that accelerated degradation after zygotic genome activation.

Pre-implantation embryo development is an intricate and precisely regulated process orchestrated by maternally inherited proteins and newly synthesized proteins following zygotic genome activation.

Such is the case of the zinc-finger protein Zelda (ZLD) that plays a key role in transcriptional activation and as a master regulator of genome activation in the earliest stages of D.m. development (Harrison et al. 2011).

Moreover, upon fertilization, there's dramatic epigenetic reprogramming to create an open chromatin state that permits the robust zygotic genome activation during the first few mitotic cell cycles (Clift and Schuh, 2013).

We demonstrate that transcription factor Nfya contributes to zygotic genome activation and DHS formation at the 2-cell stage and that Oct4 contributes to the DHSs gained at the 8-cell stage.

Since major genome activation in bovine embryos occurs at the 8- to 16-cell stage, our findings demonstrate a temporal correlation between transcriptional activation and a major rearrangement of chromatin topography in blastomere nuclei.