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Using a model of neurodegeneration that genetically targets brain cells for cell death, they follow the kinetics and nature of the immune response following injury and find that peripheral macrophages and resident microglia clear the dying cells.
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Genetics-based diagnostic tests for endometriosis and genetically targeted therapies hold the promise to diagnose and treat women at a younger age and allow physicians to better advise women regarding prognosis.
Genetically targeted magnetic control of the nervous system.
So where will we be 125 years from now? Genetically targeted and stem-cell therapies will be able to control most common cancers, as well as address many hereditary and degenerative diseases.
But the continuing trial of the melanoma drug, PLX4032, has ignited an anguished debate among oncologists about whether a controlled trial that measures a drug's impact on extending life is still the best method for evaluating hundreds of genetically targeted cancer drugs being developed.
But many vaccines and genetically targeted drugs are ineffective when delivered via the lungs.
Companies worry that genetically targeted therapies in effect reduce the market for a given drug.
APEX2 was genetically targeted to the C-terminus of hTAC to orient APEX2 towards the cytosol (Fig. S1A).
Adoptive immunotherapy using genetically targeted T-cells has recently begun to achieve impressive clinical impact in selected tumor types.
Genetically targeted inbred mice represent a powerful tool to interrogate the relationship between immune-related genes and gallstone susceptibility.
Optogenetic tools are DNA-encoded molecules that, when genetically targeted to cells, enable the control of specific physiological processes within those cells through exposure to light.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com