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The genetically "responsive" individual who is at increased risk for cancer caused by subcutaneous or topical or intratracheal polycyclic hydrocarbons is at decreased risk for toxicity of the bone marrow and leukemia caused by oral benzo[a]pyrene (when compared with the genetically "nonresponsive" individual receiving the same dose of the same xenobiotic).
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Moreover, the low frequency of genetically defined responsive patient subsets raised the issue that a reliable representation of genetic diversity requires the consideration of a far broader sampling of individuals within a specific cancer type than previously assumed.
If, on the other hand, both the response and IoR are high, this is most likely due to patients being genetically more responsive to GH (i.e. patients are high responders).
On the other hand, skin AHH activity is never induced by methylcholanthrene in DBA/2J mice, a genetically non-responsive strain.
ELPs are genetically engineered, thermally responsive polypeptides that preferentially accumulate in solid tumors subjected to focused, mild hyperthermia.
Optogenetics, based on genetically encoded light-responsive proteins, has the potential to revolutionize manipulation of signal transduction processes.
In the recent years, this goal has become progressively achievable through the field of optogenetics, which utilizes light as a non-invasive means to control genetically encoded light-responsive proteins.
They turned to optogenetics, in which cells are genetically endowed with light-responsive molecules that trigger signaling cascades.
Genetically engineered, genetic engineering.
The genetically tractable acid tolerance response (ATR) that enables enteropathogens to survive harsh acidity was screened for signaling pathways responsive to RNS.
Dopaminergic imaging studies performed in a few cases with classic DOPA-responsive dystonia (mostly genetically not confirmed) have shown no evidence of reduced nigrostriatal innervation (Snow et al., 1993; Jeon et al., 1998).
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CEO of Professional Science Editing for Scientists @ prosciediting.com