Sentence examples for genetically implicated in from inspiring English sources

Distinct amyloidogenic polypeptides are genetically implicated in the progression of human neurodegenerative disorders, including Alzheimer's, Parkinson's, polyglutamine, and prion diseases.

HNF4G, hepatocyte nuclear factor 4G, has been genetically implicated in obesity [ 62].

PRKAG2, protein kinase, AMP-activated, gamma 2 non-catalytic subunit, has been genetically implicated in blood pressure control [ 61].

eRREB1, ras responsive element (zinc-finger) binding protein, has been genetically implicated in type 2 diabetes associated end-stage kidney disease [ 60].

Interleukin 13 is a 12-kDa-protein product, produced by Th2 cells which are genetically implicated in the pathogenesis of inflammatory and immune systemic diseases, such as asthma and atopy.

Mutations in MBD1, MBDs 3 to 6, SETDB1, and SETDB2 have been genetically implicated in autism (www.gene.sfari.org), and mutations in MECP2 are responsible for Rett syndrome, a neurodevelopmental disorder that shares features with autism (Chahrour & Zoghbi, 2007).

Thus our unbiased way of defining functions central in EAE conform to previous knowledge about central mechanisms in autoimmune inflammation, indicating that these mechanisms are partially genetically regulated, as implicated in the MS GWAS.

These experiments genetically implicate WWP-1 as being a key player in the DR pathways of longevity.

SESN2, an antioxidant protein, has been implicated in genetically determined emphysema.

Moreover, hypercholesterolemic mice with genetically engineered deficiencies in proteins implicated in HDL metabolism have strongly atherosclerotic phenotypes, providing compelling evidence that HDL is a key modulator of atherosclerosis in animal models.

Over the years multiple proteins have been noted to interact with the PPP1R15-PP1 core holoenzyme, but none has proved generalizable across experimental systems or successfully implicated in the genetically well-characterised role of the complex to promote eIF2α dephosphorylation (Hasegawa et al., 2000a, 2000b; Wu et al., 2002; Hung et al., 2003; Shi et al., 2004).