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Controversy and lawsuits may have jeopardized the future of one of the most promising of these startups, Renaissance RX, whose business model revolved around determining patients' genetic responsiveness to certain medications, based on the results of DNA cheek swabs.
Genetic responsiveness (e.g. sex or strain of animals) or in-flight environmental conditions other than microgravity (e.g. pCO2 levels) may have elicited different bone adaptations in STS-131 and Bion-M1 mice.
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The greater responsiveness of NlucP as a reporter may be particularly important when the underlying genetic response of interest is subtle (Supplementary Figure s9).
Genetic aspects of responsiveness to HBsAg were also taken into account, linking responsiveness with the human leukocyte antigen system [ 37, 38].
We hypothesized that genetic variation affects responsiveness to 17-alpha hydroxyprogesterone caproate (17P) for recurrent preterm birth prevention.
To determine if prespecified genetic polymorphisms influence responsiveness to vascular endothelial growth factor (VEGF) inhibition in neovascular age-related macular degeneration (nAMD).
First, mean copulation latency for females varies substantially across lines, indicating genetic variation in responsiveness.
Similarly, the genetic determinants of responsiveness to estrogens and mammographic density remain poorly defined.
Somatic EGFR mutations have been reported to be the genetic events underlying responsiveness of non-small cell lung cancer to the small molecular EGFR-inhibitor gefitinib [ 20].
Research aimed at the identification of genetic classifiers for responsiveness to specific systemic therapies is expanding rapidly and should lead to clinically useful tests in the coming years.
This strategy will provide the highest chance of identifying genetic predictors of responsiveness to folate whilst simultaneously provide us with a resource, as knowledge of the genetics of these pathways increases, for future refinement and identification of other associations.
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