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Conversely, genetic reduction of Gale in liver improves glucose tolerance.
Genetic reduction of the tyrosine phosphatase STEP reverses cognitive and cellular deficits in a mouse model of Alzheimer's disease.
Similarly, genetic reduction of cytosine methylation in a ddm1 mutalso8,39,40 also caused increased accessibility of the tested fragments (Supplementary Fig. S6).
Kaphzan, H. et al. Genetic reduction of the α1 subunit of Na/K-ATPase corrects multiple hippocampal phenotypes in Angelman syndrome.
Genetic reduction of HIF-1α in our mouse model of simulated menses demonstrated normal onset of active bleeding but significantly delayed endometrial repair.
Genetic reduction of KCNQ channel activity as a result of mutations causes various human diseases such as epilepsy and arrhythmia.
Here we determine the contribution of each of the three RAMPs to blood pressure control in response to exogenous AM and CGRP by measuring the blood pressure of mice with genetic reduction or deletion of the receptor components.
Using genetically engineered mouse models, we show that hepatocyte-specific expression of unconventional prefoldin RPB5 interactor (URI) leads to a multistep process of HCC development, whereas its genetic reduction in hepatocytes protects against diethylnitrosamine (DEN -induced HCC.
Thus, a weaker phenotypic signal of genetic reduction due to bottlenecks is an expected result rather than a contradiction among genetic and craniofacial markers.
There is also strong evidence that the genetic reduction of HDAC4 in skeletal muscle can contribute to an overall improvement of HD phenotypes [21, 22].
Genetic reduction of ACAT1/SOAT1 in mice decreased the concentration of cholesterol esters in the brain by 86% (Hutter-Paier et al., 2004).
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