Lehrer (2016) suggests that researchers use G*E responses to refer to situations where the effect of exposure to an environmental factor on a behavior is conditional upon a person's genotype and G*E modifications to refer to differential genetic reactions to environment.
In response to mild cold stress, ∼4−6○ C, a cascade of genetic reactions are triggered that greatly enhance the tolerance to later, more severe sub-zero temperatures.
To allow for simulation of the bifurcated cycle and enable oxoglutarate production, we added the three missing reactions (without genetic evidence), and restricted reaction directionality to that observed in the study.
Research on genetic change in reaction norms could be usefully accompanied by experimental studies of selection responses by reaction norms induced by key metrics of climate change, such as temperature.
Manual curations were performed to establish gene-protein-reaction (GPR) associations, which connect genetic data to reactions in the metabolic network and allow for subsequent exploration of metabolic phenotypes using genetic perturbations.
The genetic line-specific reaction norms for PC1 of each of the modules can be seen in Figure 3.
For instance, Kelley and Ideker (2005) detected different interaction types by searching for network motifs and integrated information from genetic, physical and reaction networks.
Previous studies have reported significant genetic variability for reaction to stalk rot pathogens, identified sources of resistance, and determined the mode of inheritance of the traits for both Fusarium stalk rot and charcoal rot (Bramel-Cox et al. 1988; Sahib et al. 1990; Pecina-Quintero et al. 1999; Tesso et al. 2005).
Networks of genetic and metabolic reactions, underlying intra-cellular processes, are interconnected multi-step chemical reactions having widely different time scales.
From all reactions 124 (9.3 %) are exchange reactions, 130 (9.7 %) transport reactions, 364 (27.2 %) enzymatic reactions without known genetic association and 849 (63.5 %) enzymatic reactions with known genetic association (Additional file 1: Table S1).
