Despite the clear genetic prerequisite for mutations in downstream components of the Wnt/ β-catenin-signalling pathway that result in its constitutive activation, heterogeneous intratumour expression and subcellular localisation of β-catenin is commonly observed in colorectal cancer.
Therefore, identification of stored serum samples was crucial for the study but at the same time a limiting condition, especially as we also wished to include patients with HLA DQ2/8 i. e. those with a genetic prerequisite to develop CD [ 22].
Unlike naked cells, these containers are not dissolved by detergents, allowing us to solubilize the GPCR proteins in situ while maintaining an association with the protein's genetic information, a prerequisite for directed evolution.
No prerequisite for genetic counseling students, genetics or neurology residents/fellows or post-docs.
Therefore, assessment, documentation, analysis and conservation of the extant genetic diversity are essential prerequisites to mine useful genes for the development of the new, adaptive cultivars (Chang 1984).
It is believed that genetic susceptibility is a prerequisite for the development of T1D; however, not all genetically predisposed individuals develop clinical disease and subjects with low risk or protective genes also have been found to develop T1D.
Cloning is a prerequisite for genetic engineering, the process of altering or adding genes to an embryo.
The availability of multiple high-quality reference genomes from diverse genetic backgrounds is a prerequisite for effective mining of crop genomes30, especially in studies involving wild germplasm.
Three hypotheses were formulated on the relationship between habitat connectivity, as a prerequisite for genetic exchange, and habitat aggregation and contrast between habitat types.
Despite the advantages of efficiency in resequencing, the availability of a series of reasonable and adequate genetic resources is a prerequisite for the implementation of this technology.
