Li, Q. & Eichten, S. R. Genetic perturbation of the maize methylome.
Liberali, P., Snijder, B. & Pelkmans, L. Single-cell and multivariate approaches in genetic perturbation screens.
Wilczek, A. M. et al. Effects of genetic perturbation on seasonal life history plasticity.
Characterization of luminal integrity and function upon mechanical and genetic perturbation.
The resulting genetic perturbation signatures reflect many different properties.
Canalization, or phenotypic robustness in the face of environmental and genetic perturbation, is an emergent property of living systems.
With or without genetic perturbation, migration persistence, which reflects the polymerisation of cortical branched actin, appears to determine the S-phase entry.
Heatmap representing correlations of fitness scores between mSWI/SNF complexes genes in genome-scale shRNA-based genetic perturbation screens (Project DRIVE, Novartis).
The data are assembled into a genetic perturbation network that shows different connectivities for different classes of regulators.
Genetic perturbation revealed physiological roles for mitochondrial enzyme COX10-mediated oxidative phosphorylation in T cell quiescence exit.
We anticipate that high-confident libraries of MS assays for cross-linked peptides distance constraints can, in future work, be used to determine dynamic changes of the quaternary structures in biological samples after, for example, chemical and genetic perturbation.
