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Despite the challenges in study design and analysis that face investigators in this area, the identification of genetic pathways that regulate longevity may suggest potential targets for therapy.
In invertebrates, the molecular genetic pathways that regulate life span and senescence are being identified; surprisingly, they are conserved through evolution.
These findings highlight conserved metabolic and genetic pathways that regulate aging.
Overall, little has been known about the mechanisms controlling cortical development and the genetic pathways that regulate them.
We therefore postulated that the egg-laying defects seen for Smr mutant females result in part from disrupted genetic pathways that regulate the development of somatic follicle cells.
At this point we relegate the reader to the review of North and Sinclair [ 83] which summarizes how the genetic pathways that regulate aging in model organisms influence the cardiovascular health state.
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The genetic pathways that regulated cell lineage fate during the development of APL remain unclear.
One fat body-enriched gene, female-specific independent of transformer (fit), is a downstream target of the somatic sex-determination hierarchy, a genetic pathway that regulates Drosophila reproductive behaviors as well as expression of some fat-expressed genes; three other mating-responsive loci are also downstream components of this pathway.
This observation indicates that muscle hyperplasia depends on the genetic regulatory pathways that regulate the initial (embryonic) myogenesis.
Most rare diseases are inherited, and advances in genomic technologies are rapidly increasing our knowledge of their genetic basis and the pathways that regulate key cellular processes.
In cancer, the most frequent genetic alterations are found in a number of pathways that regulate crucial cellular processes [ 38, 39].
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