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However, while the variants identified in the lung cancer GWAS studies, and in many other GWAS, point to potentially important loci, the functional relationship between the SNP and a molecular genetic mechanism to explain the biological phenotype is not apparent.
In turn, this elevated mutation rate could provide an underlying genetic mechanism to explain why robustness promotes evolvability.
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The use of genetic mechanisms to explain familial aggregation of hypertension is a very good example.
Third, we showed that genetic introgression was the most likely mechanism to explain the cases of discordance.
That weaker signals of genetic relatedness might exist year round could provide a mechanism to explain nepotism between unfamiliar kin.
We've not identified the precise mechanism to explain HIV controllers but we know that of all the genetic influences involved, this is by far the most important," Dr Walker said.
First, it provides an internal mechanism to explain the Industrial Revolution.
There is no known biological mechanism to explain how non-ionizing radiation might lead to cancer.
The unique biology of hybrids has led to the proposal of many hypothetical molecular, genetic and epigenetic mechanisms to explain the differences between progeny and progenitors [ 3– 9].
Kepler, however, sought physical mechanisms to explain his mathematical result.
Here as well there were plausible biological mechanisms to explain the observed associations.
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