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These approaches can be used to engineer aREDs within novel genetic contexts for the predictable, dynamic regulation of gene expression in vivo.
Most of the traits showed low correlations between families in different genetic contexts and, occasionally, this had a large effect on rankings.
To address this problem we sought to generate zinc finger-recombinase fusion proteins (RecZFs) capable of site-specific function in a diversity of genetic contexts.
By allowing this variability to be easily measured without potential user bias in selecting regions of interest, STXMPy thus empowers analysis allowing biological comparisons and tests of whether defined genes or genetic contexts significantly alter composition of cells or organelles.
Also, after movement and expression of the transgenes in other genetic contexts (e.g. wild relatives), an entirely different suite of organisms can get into contact with the novel transgene products.
They have brain effects, but the brain effects vary across classes of individuals in ways that depend on other environmental and genetic contexts (see Kendler and Prescott 2006 for a comprehensive review).
Moreover, these elements are sufficient to induce ribosome arrest in other genetic contexts [42].
Some of these ESRs were experimentally validated using minigen reporter assays under different genetic contexts.
Such individual elements can acquire opposing activities upon changes of environment or in different genetic contexts.
Important questions relate to the behavior of NB 6-4 in different genetic contexts and the exact role of EN and GsbN in this process.
To further elucidate the biological relevance of Int6 and Mek signaling, we took advantage of the ease with which signaling pathways can be altered pharmacologically in specific genetic contexts in the zebrafish system.
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