The etiology of these conditions is often complex, influenced by both genetic context and the environment.
Because a single reporter gene replaces each deleted gene, interrogating this reporter provides a sensitive probe into different chromatin environments while controlling for genetic context.
We discuss the engineering of 'parts' that influence transcriptional throughput including promoters, terminators, and transcription factors as well as the genetic context of the expression cassette.
TAL (transcription activator-like) effectors from Xanthomonas bacteria activate the cognate host genes, leading to disease susceptibility or resistance dependent on the genetic context of host target genes.
Moreover, spontaneous mutations can occur on any number of genetic backgrounds, potentially revealing critical genes that require a specific genetic context.
EB1 is up-regulated in early and field carcinogenesis in the colon, and the cellular/nano-architectural effect of EB1 knockdown depended on the genetic context.
We then tried to obtain the double ribH mutant by disrupting ribH2 in a ribH1 mutant genetic context.
In its natural genetic context, the lux promoter is located between the divergently expressed genes luxR and luxI.
The genetic context of SMA represents an intriguing target for a number of therapeutic strategies, including trans-splicing.
This comparative microbiome data provides a critical genetic context for understanding food safety, animal nutrition, animal health and well-being.
Whereas the efficiency of pre-RC-formation at DS was not affected by its genetic context (Figure 3), the initiation pattern was slightly more relaxed (Figure 6).
