The correlation between the genetic polymorphism, plasma concentration of chemotherapeutic agents and clinical outcomes was also explored.
Question (2) in our paper describes the primary study question (differences in tongue-pressure amplitudes as a function of taste quality, stimulus concentration, genetic taste status, and age group) without consideration of the covariates.
The approach first tests whether these potential covariates vary as a function of the main factors in the model (in this case, questions (1a) and (1b), exploring whether taste intensity or palatability varies as a function of taste quality, stimulus concentration, genetic taste status, and age group).
The compound 3- 2-furyl -5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- isonicotinoyl pyrazole (2f) was active against all the INH-resistant strains regardless of the genetic background at concentrations two- to four-fold its minimum inhibitory concentration against M. tuberculosis H3- 2-furyl -5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- isonicotinoyl pyrazole
One is the analysis of biological data — ferreting out the connections between genetic variations or concentrations of biological molecules in the cell and the processes underlying disease or physiological development.
ENU mutants were generated in different genetic backgrounds at concentrations of ENU in the range of 3 7 mM.
Since soy seed isoflavones are regulated by multiple genetic factors, their concentrations in seed are highly variable [ 1, 12– 12].
In addition to assessing cell survival, the researchers determined genetic expression and concentrations of the antiapoptotic proteins Bcl-2, Bcl-xL, and survivin, as well as classical and nonclassical estrogen receptors.
Although BNP and NT-proBNP, which have both emerged as important markers of cardiac function, have a common genetic precursor, blood concentrations of NT-proBNP differ markedly from and exceed those of BNP due to differential clearance mechanisms and a longer half-life (5– 10).
Idiosyncratic adverse drug reactions are often considered to be concentration-independent, but genetic factors that affect drug concentration by their role in drug disposition also make a contribution to susceptibility to some adverse drug reactions.
