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However, in samples that were collected 10 or more days apart, six of seven subjects were classified as having compartmentalized viral populations, highlighting the necessity of contemporaneous sampling for genetic compartmentalization studies.
All Bonferroni-corrected Slatkin Maddison P values for genetic compartmentalization between any two subsets were greater than 0.05 in all four participants.
Despite the previously reported genetic compartmentalization and gp120-specific bias of colostrum HIV Env-specific B cells, the colostrum Env-specific mAbs described here demonstrated a broad range of gp120 epitope specificities and functions, including inhibition of epithelial cell binding and dendritic cell-mediated virus transfer, neutralization, and antibody-dependent cellular cytotoxicity.
Genetic compartmentalization was evident in only one out of six subjects in whom contemporaneously obtained samples were studied.
While these studies generally point to genetic compartmentalization between blood and lung, the causes, degree, and extent of compartmentalization have not been fully resolved.
These studies all indicate some degree of genetic compartmentalization between lung and blood as well, though the methods used to define compartmentalization varied.
Similar(49)
However, the intermingling of these clades with clades comprised of both genital and blood sequences and the absence of tissue-specific genetic features suggests compartmentalization between blood and genital tract may be due to viral replication and proliferation of infected cells, and questions whether HIV-1 in the female genital tract is distinct from blood.
It might also indicate a distinct genetic basis for compartmentalization in "anammox" species compared with organisms of the class Planctomycetia.
Here we adapt liposome encapsulation to enable the modular, controlled compartmentalization of genetic circuits and cascades.
The defining feature of the eukaryotic cell is the compartmentalization of genetic material inside the nucleus.
Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elements, suggesting that compartmentalization is important for genome function.
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