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In summary, our findings that inhibition of autophagy at both genetic (by ATG7 and Beclin 1 knockdown) and pharmacological (chloroquine and 3-MA treatment) mean potentiated the proapoptotic effects of ZD6474 in glioblastoma cells in vitro and in vivo.
Below are the most recent publications written about "Databases, Genetic" by people in Profiles.
Additional areas of research include identifying novel genetic by environment interactions important to the onset of asthma.
Much of the work is genetic: by turning off the function of a certain gene, for instance, researchers can see what effect it has.
This graph shows the total number of publications written about "Databases, Genetic" by people in Harvard Catalyst Profiles by year, and whether "Databases, Genetic" was a major or minor topic of these publication.
This graph shows the total number of publications written about "Transcription, Genetic" by people in Harvard Catalyst Profiles by year, and whether "Transcription, Genetic" was a major or minor topic of these publication.
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Thus the resource consumption rate appears as a key parameter to account for variation in life-history traits, and more specifically genetic-by-environment aspects.
Surprisingly few studies have been carried out to estimate correlations between life-history traits in two or more environments, which still represents the direct experimental method to untangle the genetic and environmental components of the trade-off variation, and possible genetic-by-environment interactions.
We demonstrate here that a randomized-treatment study on the experimental diallel not only confirms a treatment effect but also estimates higher-order genetic-by-treatment interactions.
Little of the phenotypic variance across cycles (and thus years) was additive genetic variance, with the majority likely being caused by genetic-by-year interactions given the complexity of the silage compositional traits and their interaction with grain yield.
The increased structure of the NCRPIS panel also suggests each subpopulation may possess a unique evolutionary history with selection acting on alternate genetic effects in each subpopulation due to epistatic and genetic-by-environment interactions.
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