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OA is a multifactorial disorder that can be divided in non-genetic (age, gender, obesity, mechanical stress, inactive lifestyle, joint trauma, patient occupational activities) and genetic (altered gene expression patterns of the cartilage and subchondral bone) factors.
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This genetic change altered lysine amino acids into aspartic acid in 974 position of the coded protein (K974D).
Several factors such as psychological, environmental, genetic factor, altered serotonin metabolism and altered sleep physiology are involved in the pathogenesis of fibromyalgia.
Results obtained indicate that genetic modifications altered wood lignin-S/G ratio.
Genetic factors, altered iron metabolism and dopaminergic dysfunction have been thought to be involved in the pathophysiology of PLMd.
Batty wants to have his genetic code altered to extend his assigned four-year life span.
GE plants or animals have had their genetic makeup altered to exhibit traits that are not naturally theirs.
We next determined if PP2A inhibition with pharmacological or genetic means altered Berberine-induced AMPK phosphorylation.
An assumption was that genetic modifications altered Igf2 expression alone.
Despite often significant difficulties in the interpretation of their relevance to human disease, mouse models have provided experimental tools to investigate genetic pathways altered in breast cancer.
However, the diversity of genetic pathways altered by loss of peroxisome function underscores the widespread and varied responses seen in both the clinical and biochemical presentation of PBDs.
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