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Genes that affect a pharmacological response, their number, genomic distribution, and genetic actions and interactions can be estimated and tested.
High significance GCA and SCA observed revealed the importance of both additive and non-additive genetic actions, while low GCA/SCA implied importance of dominant effects of gene.
The model allows for a further extension to discern the contributions of multiple modes of variation to TPCs through a web of genetic actions and interactions.
Current genome-wide linkage or association studies have been able to detect genetic actions of individual genes involved in the phenotypic diversity of a complex trait [5] [12].
The function of such embedment is to directly characterize specific QTL that determine ontogenetic changes of allometry and push the hypothesis tests at the interface between genetic actions and shape development.
Thus, it is likely that the metabolic pathways for a phenotypic trait or disease involve multiple interacting gene products and regulatory loci that could generate a complex network of genetic actions and interactions [3], [4].
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Evelyn Fox Keller (2000) has argued that this blending of computational and coding metaphors was productive for geneticists because it allowed the development of a notion of genetic action in absence of detailed knowledge of the biochemical structures and mechanisms in which such action was ultimately realized.
This concept was then explained in a statistical manner by Fisher [23] as the deviation of genetic action from additivity in a linear model.
In all scenarios (i) individuals were unrelated; (ii) loci were independent; (iii) all genetic action was additive; (iv) for simplicity, loci were assumed to be in Hardy-Weinberg equilibrium; and (v) each scenario was replicated 100 times, except for case control scenarios with λ = 0.02 where 500 replicates were run.
But the contribution of the paper is to show that genetic management of infectious disease is also theoretically possible as a control measure complementary to non-genetic actions.
Subjects with the homozygous major allele genotypes for all three IL6 polymorphisms showed larger IL-6 responses to increased CO, but only for for IL6 rs2069832 was a similar genetic inter-action seen with increased NO2 (Table 4).
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