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Cancer is a complex disease, arising from the interaction of our genes with numerous factors in the environment.
Most surprising was the presence of small predicted non-TE genes with numerous homologs in Pgt.
YY1 has been implicated in the expression of many genes with numerous functions [ 46].
Sanderson and McMahon [ 10] take a completely different perspective and infer the organismal phylogeny using genes with numerous duplications.
Among the seven genes with numerous Alu mediated recombination events reported [ 16], four genes (BRCA1, MLL, MSH2 and VHL) are contained in CL1 and CL2.
As expected under this selective pressure, genes with numerous and/or closely spaced histidine codons have evidently been counterselected in the genome of P. carbinolicus.
Similar(51)
Multiple protein bands were detected in blots for TCF7L2, a gene with numerous alternatively spliced transcripts[29], but no mutant proteins were identified that correlated with the mutation data.
SYNE1 is a large gene with numerous annotated transcripts.
Chromosomal rearrangements of the mixed lineage leukemia (MLL) gene with numerous partner genes are frequently found in acute myeloid and acute lymphoblastic leukemia.
Furthermore, PKD1 is a highly polymorphic gene with numerous sequence variants [ 10, 11] (Human Gene Mutation Database [HGMD]; http://www.hgmd.cf.ac.uk/ac/index.php[ 12]).
In addition, matrix metalloproteinases MMP2 and MMP9, the cell growth and cell cycle regulators CDKN2A, BCL2, and EGFR, and Methylentetrahydrofolate reductase (MTHFR) genes are among the top genes associated with numerous disease conditions.
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