Alternative splicing generates a vast diversity of protein isoforms from a limited number of protein-coding genes, with many of the isoforms possessing unique, and even contrasting, functions.
Currently, more than 25 different loci encode ASD-susceptibility genes, with many more being investigated [44].
It is likely that for popular genes with many interaction partners, not all interactions are of equal relevance.
Does the ROSG model explain extremely long genes with many exons embedded between very long regions of introns?
The top 100 network for AUP evaluation was constructed by adding connections between genes with many overlapping GO groups.
We concede that, since each gene is represented by a different number of probes, genes with many probes contribute proportionally more weight to the final V2 statistic.
Transcripts deadenylated at egg maturation and after fertilization that are also decreased upon egg aging, are derived from genes with many different functions (Table S3).
In addition, the chaperone Hsp90 is known to confer robustness to both environmental and genetic change [16], and the inhibition of genetic hub genes in C. elegans (genes with many genetic interactions) produces highly variable phenotypic outcomes [8].
Large-scale tumor sequencing studies have identified a rich source of naturally occurring mutations in the protein kinase genes with many being simple single nucleotide polymorphisms (SNPs) [23] [32].
Thus, IPNs reflect associations predicted from multifunctionality alone, that genes with many functions are more likely to interact, and if these interactions show gene function prediction performance, it can be ascribed to multifunctionality alone.
For each gene only the SNP with the lowest p-value was used, to avoid introducing a bias towards genes with many low p-value SNPs in linkage disequilibrium with each other.
