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The difference is due in part to the unique bias of the Tribolium X discussed below but because the pattern of increased proportion of male-biased genes with increasing fold difference is the same in the two species, statistical differences in the power to detect sex bias at low fold change may also contribute.
By contrast KRT7, KRT8, KRT15 and KRT19 showed neutral or declining transcript levels (Figure S1), even though they shared the same pCs as genes with increasing abundance.
Biological replication in an independent test set of 58 lung samples confirmed the altered expression of ten genes with increasing COPD severity, with eight of these genes (NNMT, THBS1, HLA-DPB1, IGHD, ETS2, ELF1, PTGDS and CYRBD1) being differentially expressed by greater than 1.8 fold between mild and moderate COPD, identifying these as candidate determinants of COPD severity.
CL5 includes 30 genes with increasing expression throughout oocyst development.
Similar conclusions were drawn when we plotted the frequency of genes with increasing fold change.
We sort all the DR genes with increasing order of that likelihood.
Similar(31)
Of the 488 genes with increased mRNA levels, 90% were associated with increased H3K4me3 around the TSS, with approximately 65% showing a >2-fold>2-foldse (data not shown).
Humans, for example, only had 84 genes with increased copy numbers over those of our closet relatives.
No clear themes in glycogene function were discernable among the genes with increased expression.
The spectrum of genes with increased transcription covered all aspects of nucleotide biosynthesis and interconversion (Figure 6).
There were four genes with increased expression related to ubiquitin, Trim 63, Fbxo32, Rnf 39, and Cblb.
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