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Lassmann et al. studied 287 target sequences in 22 Caucasian colorectal tumors and found frequent aberrations in specific regions of chromosomes 7, 8, 13, 17, 20 and suggested some candidate genes with frequent deletion or amplification in these regions [22].
Genes with frequent rare variants need to be appropriately ranked in order to reduce false associations and streamline clinical analysis.
Interestingly, genes with frequent methylation in male breast cancer (MSH6, CDH13, PAX5, PAX6 and WT1) were also very commonly methylated in female breast cancer.
Fifty genes with frequent (>30%) methylation/deletion aberrations in prostate tumors with different pathomorphological characteristics were revealed using NotI-microarray technology.
Is the rate of these events predictive of rates of protein evolution and is any such correlation itself owing to genes with frequent noncrossover events being genes with high crossover rates?
The proposed route of IS evolution via AS is likely to be common in poorly conserved regions of protein-coding genes with frequent AS events (e.g. 5'- and 3'-regions of many genes) but rare in conserved portions of protein-coding genes.
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This is because with the τ-uniform sampling one chooses the genes with less frequent τ values more often than genes with more frequent τ values.
Research has been focused on the findings of possible driving genes of this disease, especially those genes with high frequent mutations, over-expressions, or fusions for a long time.
Although genetic changes were only detected in tumor epithelial cells, all cell types underwent significant gene expression changes, with frequent alterations detected in genes encoding receptors and secreted proteins.
Thirteen microsatellite markers, which were mapped to and/or very close to the tumor suppressor genes or regions with frequent LOH in breast cancer, were used.
Mutations in the IFN gamma receptor genes are associated with frequent recurrences or the most serious forms of the disease [ 11- 13].
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