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By matching phenotypic profiles to our identified signatures, we assign genes with complex phenotypic profiles to multiple functional classes.
We find that genes with complex multiprotein regulation can have peaked burst-size distributions in contrast to the geometric distributions found for simple models of transcription regulation.
Here, we present a combined methodological approach of tissue specific and conditional genetic manipulations, with large-scale search for altered gene expression, as an experimental framework to investigate the role of genes with complex functions and/or complex expression patterns.
Songbirds represent an important model organism for elucidating molecular mechanisms that link genes with complex behaviors, in part because they have discrete vocal learning circuits that have parallels with those that mediate human speech.
In a broader perspective, our results suggest new mechanisms to be further explored in the analysis of the association of genes with complex traits.
The genes with complex structures usually consisted of some short exons in the LRR region, and most of them were interrupted by a phase-2 intron containing 72 nucleotides that only encoded 1 LRR repeat.
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Joobeur, T., King, J. J., Nolin, S. J., Thomas, C. E. & Dean, R. A. The fusarium wilt resistance locus Fom-2 of melon contains a single resistance gene with complex features.
On the other hand, syndromic 46,XY DSD was also caused by deletions of a single gene with complex functions.
A classic example of a gene with complex regulation is hTERT.
The inducible form of cyclooxygenase, COX-2, is an immediate-early response gene with complex regulation that plays an essential role in vascular homeostasis and inflammation.
Osteopontin is an important pro-metastasis gene with complex molecular regulation making its study in human primary and metastatic CRC a particular interest.
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