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Using comparative sequence analysis of Drosophila and human FIBP genes we demonstrate a remarkable conservation of their structural architecture suggesting that FIBP from vertebrates and insects are genuine homologues.
By compressing spheroids consisting of cancer cells overexpressing anti-apoptotic genes, we demonstrate that mechanical stress-induced apoptosis occurs via the mitochondrial pathway.
Next to the variety generated by the large number of genes, we demonstrate here that the B30.2 domain of fintrim genes has evolved under diversifying selective forces.
Through automated and manual analysis of the selected genes, we demonstrate that the selected features expose relevant pathways that other approaches would have missed.
Using different sets of proteins encoded by known disease genes, we demonstrate that our novel method allows for assigning known disease genes specifically to the correct phenotype.
The majority of these elements lie in the intergenic regions segregating adjacent Hox genes; we demonstrate that they possess efficient enhancer-blocking activity in mammalian cells.
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Finally, using a phylogenetic study based on 667 concatenated core genes, we demonstrated the position of R. felis within the spotted fever group.
Through automated and manual expert analysis of the selected genes, we demonstrated that the selected features exposed biologically-relevant pathways that other approaches would have missed.
On the basis of phylogenetic analyses and characteristic motifs of GAox genes, we demonstrated a rapid expansion and functional divergence of the GAox genes during the diversification of land plants.
Previous research has confirmed that the endogenous cellulase genes we demonstrated are most highly expressed in the anterior midgut are also most highly active in the anterior midgut [ 27], making it the site of both cellulase translation and action.
In two of them corresponding to novel genes, we demonstrated that they are specifically expressed in the cytoplasm of follicular cells in basal oocytes at the time of choriogenesis.
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