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Most approaches to gene therapy use viruses as the vehicle to convey genes to target cells.
Gene therapy has historically focused on delivering protein-coding genes to target cells or tissues using a variety of vectors.
An experimental study with rats genetically engineered MSCs to express "suicide genes" to target glioma.
Therefore, the recent trial of PEI delivery of genes to target cells in vivo were done mainly by direct injection either into the target tissue[13, 14, 37] or into its blood supply[38, 39] or by introduction with an appropriate cell vector[20].
The International Potato Center in Lima, Peru is looking for genes to target in the sweet potato weevil, a beetle whose larvae ravage sweet potatoes globally.
Further studies involving tailored design of biomaterials could benefit from the knowledge presented here regarding MMP-specific genes to target particular MMP-related peptide sequences for certain types of tissue regeneration.
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This involves the insertion of a corrected gene to target cells to overexpress and replace the defective ones responsible for disease.
Where Pfaffl [ 55] uses ratios of the control gene to target gene values, we use the differences between the corresponding logarithms of these values.
Means±S.D. (technical) were calculated per sample measured, and S.D. propagated from normalization gene measurements to target gene measurements.
We find that most pluripotency genes reconnect to target enhancers during reprogramming.
The filtered 189 genes were mapped to target genes in the RegulonDB network.
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