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Chromosomes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex patterns requiring the orchestration of a huge number of DNA loci and molecular regulators.
A characteristic feature of all organisms is modular organisation: the tendency for groups of genes to interact in such a way as to limit the extent of pleiotropic effects among characters belonging to different functional complexes.
More recently, gene interaction information has been introduced into the gene selection (GS) process to account for the known ability of genes to interact or react within pathways or common modules.
It is hypothesized [29] that the mutually inhibitory dopamine melatonin systems are subject to seasonal changes such as temperature allowing season-of-birth and variations of the candidate genes to interact across different dopamine levels during gestation.
For genes to interact they both have to be upregulated.
However, it is also possible for the genes to interact so that one gene may mask or amplify the effect of another gene.
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We expect that Nature does not realize such models: they are implausible as they require essentially every gene to interact nontrivially with every other.
In essence, this allows a single gene of relatively short length to encode a large protein system by allowing multiple peptide sequences encoded from that gene to interact and form a large multimeric protein.
This work also illustrates that key transcription regulators are sufficiently conserved between Xenopus and humans (Amir et al., 1999), allowing the human MeCP2 gene to interact (Marshak et al., 2012) with native Xenopus pathways (Stancheva et al., 2003).
Despite the informatic software not predicting this gene to interact functionally with GR, we found that SIAT4B significantly inhibited Gc transactivation in HeLa cells, indicating the necessity for experimental verification of bioinformatically identified "hits".
Most of the polysaccharide used for coating the MNPs are either negatively charged or neutrally charged (except chitosan which is positively charged); chemical modification was required for allowing the gene to interact with polymer coating on the MNPs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com