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Another surprise: Many genes produce half-baked proteins that need to interact with other proteins, made by other genes, to function.
For these genes to function properly, the relative amount of their products must be balanced.
The principal energy generating system in animals is the oxidative phosphorylation (OXPHOS) pathway, which depends on the tight interaction of nuclear and mitochondrial encoded genes to function properly.
Considerable fine-tuning of methods is clearly still needed to make functional screening representative of the environmental diversity and to boost its efficiency in assigning genes to function.
The mitochondrial electron transport chain, a central component of cellular energy production, relies on the coevolution of mitochondrial- and nuclear-encoded genes to function [ 1, 2].
Many drugs require the expression of specific genes to function, and drug function can be affected by changes in the expression level of these pharmacogenomic genes.
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Four years later, he announced that he had gotten an artificial gene to function in a bacterial cell.
The first step in linking gene to function is to define what constitutes a function, and this is not trivial.
The results of this systems ecology study demonstrate the applicability of consortium EMA, explicitly mapping the genes-to-function emergent properties associated with the connectivity of metabolic reactions via the exchange of mass and energy.
In gene function prediction, the number of positive gene-to-function relationships is far smaller than that of negative relationships.
This is the currently accepted top-down, gene-to-function molecular biology paradigm.
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