Exact(1)
When we followed the presence of histone modifications alone or in combination with each other during differentiation, we found that the most prevalent mark characteristic for active genes, the double H3K4me3/AcH3, often persisted on genes throughout the differentiation process.
Similar(59)
If different branches share a family of duplicated genes, the doubling had to occur before that branch evolved.
Mice lacking one copy of the Flii gene, the double knockout being embryonically lethal [ 23], were made as described previously [ 23] and will be written as Flii+/−.
Among the 337 up-regulated genes, 12 common genes are observed in all the mutants (Table 1), 43 common genes in the double mutant and ypr015cΔ, 21 common genes in the double mutant and ypr013cΔ and 26 common genes in ypr013cΔ and ypr015cΔ.
Among 225 down-regulated genes, 10 common genes are shown in all the mutants (Table 2), 28 common genes in the double mutant and ypr015cΔ, 14 common genes among the double mutant and ypr013cΔ and 18 common genes in ypr013cΔ and ypr015cΔ.
The overall difference obtained for expressed genes was substantial, with 1022 differentially expressed genes in the double null mutant, compared with the wild type control.
Similarly, there were 168 and 81 down-regulated genes in the double mutant and ypr015cΔ, respectively, and 26 genes in ypr013cΔ.
Cluster 2 was the only one to contain genes induced in stationary phase in strains expressing exclusively HUα2 or HUβ2 homodimers; the transcription of these genes in the double mutant and wild-type strain was similar.
To further investigate the epistatic relationship between dSmad2 and Mad in wing development, we compared single RNAi phenotypes for both genes to the double depletion situation.
We found an even greater number of downregulated genes in the double mutant (298) than in either of the single mutants using similar criteria (Table S2).
In our models, several genes exhibit the double segmental periodicity generated by FFL connected in series where the stripe number is as half as that of segmentation gene #1 (Fig. 1G I).
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