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For this we screened an established yeast model to identify genes that when overexpressed alter alpha-synuclein toxicity.
What we have here are three individuals, one of whom was my colleague at Rockefeller, Mike Young, who used fruit flies to identify genes that when mutated alter the circadian rhythm.
An international consortium of scientists, led by researchers at The Johns Hopkins University, has identified two genes that when altered are closely associated with cleft lip and/or cleft palate.
We are currently only aware of a handful of genes that when mutant cause hereditary cancers.
The first group are genes that when overexpressed possibly increase the metabolic burden to the cell.
Among the depleted genes, we identified genes that when overexpressed may cause undesirable increase in n-butanol inside the cell.
This approach led to the identification of six non-essential genes that when deleted enhance the toxicity of α-syn toxicity: ISC1, ELO1, ELO2, ELO3, OSH1, and OSH2.
The original list of 161 genes was identified on three platforms and was enriched for genes that when mutated lead to skeletal anomalies.
Antibiotic sensitivity genes are genes that when lost, confer increased sensitivity to antibiotics [ 18].
Cancer genes are defined as genes that when mutated are causally implicated in oncogenesis [ 34].
We specifically identified genes that, when silenced, resulted in prolonged C. elegans survival during infection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com