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Patterns of expression differ among organs many genes that need to be active in the liver, for instance, must remain silent in the brain.
Genetic analyses of patients with neurodegenerative disorders have identified multiple genes that need to be investigated for the presence of damaging variants.
The draft of the human genome that is now available should make that easier than it would have been a few years ago, but the chromosomal region that Dr Puca has identified still contains several hundred genes that need to be examined.In this section The old new thing Only a matter of time Good vibrations On the other seven hands ReprintsEven so, mere confirmation would be a significant advance.
Further, the available information may help to predict combinations of genes that need to be targeted simultaneously to impact orofacial development due to redundancy.
Then, circuits operating at the state OFF would be mostly based on the I1-FFL and would control genes of low demand (e.g., secondary metabolism) or genes that need to be activated in specific situations such as stress responses or during development.
We determined the individual contributions of Cat8 and Adr1 on the expression of a cohort of glucose-repressed genes and found three broad categories: genes that need both activators for full derepression, genes that rely mostly on Cat8 and genes that require only Adr1.
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Two Alaskan brown bears also showed the presence of cave bear DNA, suggesting an unexpected diffusion of genes that needs to be investigated further, he said.
Whatever the mechanism, there must be a core set of genes that needs to be maintained throughout the course of somatic evolution in the tumor microenvironment.
Thus, eQTL profiling reduced the set of candidate genes that needed to be assayed to establish the identity of the causal gene — and thereby to define a novel drug target, the Golgi transmembrane receptor SORT1.
None of these attributes on their own showed remarkable differences in identifying genes that needed to be updated (data not shown), suggesting we will need to look for additional factors or evaluate these factors in combination in order to enrich for genes whose annotations need review.
Overall, the complexity of the NB-LRR complement was reduced by 51% in Heinz 1706, and 43% in LA1589 (Additional file 6) and thus the number of paralogues of any candidate R gene that need to be analysed is halved.
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CEO of Professional Science Editing for Scientists @ prosciediting.com