These hub genes are likely control points or key genes that modulate the expression of the network-module and thereby are considered important for the observed phenotype [ 19, 21, 22].
We try to look for common patterns among genes to identify new genes that modulate longevity, and ones that regulate other genes.
With regard to a rational approach of virus attenuation, we consider a selective deletion of viral genes that modulate the immune response of the host.
Of the 41 gene variants the studies have linked to migraine risk, many are in genes that modulate electrical activity in neurons and are thought to make carriers more susceptible to CSD.
Overexpression of genes that modulate drug action, cell proliferation and apoptosis is the cornerstone for MDR.
ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation.
We have utilized a shortest-path network analysis to identify novel genes that modulate longevity in Saccharomyces cerevisiae.
Identification of genes that modulate longevity is a major focus of aging-related research and an area of intense public interest.
Recently, RNA interference (RNAi) screens in model organisms and human cell lines have successfully identified genes that modulate cell growth, apoptosis, chemoresistance, and chemosensitivity [30] [34].
PPARγ regulates the expression of many genes although the exact PPARγ target genes that modulate insulin sensitivity are as yet unidentified.
As a model to screen for genes that modulate p53 function, we previously developed a human fibroblast cell line named BJtsLT [11].
