An integrative genomics approach identifies hypoxia inducible factor-1 (HIF-1 -target HIF-1 -targetrm tHIF-1 -targetnse to hypoxia.
Combining these observations, we arrive at a putative disease module for tauopathies consisting of nine genes that form a connected subgraph (Fig. 3G).
In the small patient subset without this genetic defect, the analysis indicated that 60percentt nevertheless had mutations to genes that form part of the same signaling pathway as KRAS.
Traditional DNA-based typing focuses primarily on interrogating the exons of HLA genes that form the ARD (peptide-binding region that interacts with T cell and killer immunoglobulin-like receptors).
The differences in appearance between the sexes result from a process known as sexual selection, in which individual males with extreme ornamentation have a higher breeding success; they pass on the genes that form the basis for these features at a faster rate than those individuals lacking ornamentation.
Researchers seek, above all, to understand the functions of the specific proteins and genes that form a sophisticated and mutable virus like H.I.V., and then to concoct clever ways of preventing those genes from doing their job... Writer interviews vaccine advocate Edward Mbidde, who is the director of the Uganda Cancer Institute.
What's more, almost all of the detoxifying genes were associated with other genes that form an elaborate on-off switch that may help the bug sense chlorinated compounds.
These developmental genes fell into three categories: "gap" genes that lay out the head-to-tail body plan; "pair-rule" genes that determine body segmentation; and "segment-polarity" genes that form repeating structures in each segment.
The two other genes that form the TBR1 subfamily are EOMES (also known as TBR2) and TBX21 (also known as T-BET).
The correlation structure in genes that form cis-eQTLs were consistently found to differ markedly from that in genes that form trans-eQTLs in all tissues.
Figure 4 shows module two, where there are 36 genes that form an intensely connected subnetwork with 4 seed genes involved.
