In summary, we propose a list of 13 genes that constitute a constitutive AHR gene battery, at least in the tissues studied, in mice and rats (Agt, Car3, Creg1, Ctsc, E2f6, Enpp1, Gatm, Gstm4, Kcnj8, Me1, Pdk1, Slc35a3, and Sqrdl).
The correlation coefficient was significantly increased when only the 48 genes that constitute the overlap of the DE mRNAs/proteins were analyzed, i.e. in the population in which both partners were defined as differentially expressed (R = 0.87; Fig. 4c).
We selected several DNA polymorphisms of the three genes that constitute the hypocretin system and, using a case control strategy, we evaluated possible allelic and genotypic differences in a group of 109 CH patients and 211 controls.
Completed in 2003 after a 13-year international effort, the Human Genome Project placed the 25,000 or so genes that constitute the human genome within easy reach of researchers.
Together, the ontology of the genes that constitute the four signatures reaffirms our confidence in their predictive ability.
Supporting our observations, others have described extensive local African var diversity in studies of severe malaria, although these studies mostly analyzed transcribed var genes rather than genomic var genes that constitute the reservoir (e.g. [41], [42]).
In one instance, genes that constitute a signature are compared with genes that define response of cells to a variety of drug treatments, thus connecting drug response with a phenotype.
Although the interpretation of a FARO requires an understanding of the biological system analyzed, FARO offers an advantage over more abstract methods since FARO results may be further dissected into the individual genes that constitute the overlap.
Transcription factors of the Tcf/Lef1 family in the nucleus are then converted from repressors to activators by replacement of a repressive partner, Groucho, with the activating partner, β-catenin, thus activating transcription of an array of genes that constitute the downstream mediators of the pathway.
Complete sequences were found for 93.6% of the 482 genes that constitute the core gene set.
Consequently, there is considerable plasticity in number and type of genes that constitute members of FNR regulons in different organisms.
