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Many of the enriched GO categories pertain to neuronal activity while other categories include those involved in cell surface receptor-linked signal transduction and intracellular signaling cascades, and genes that bind to other proteins (GO molecular function: protein binding).
We defined the enrichment of over under -expressed genes that bind within a distance d as
Nor did NRSF affect genes that bind loosely.
First all genes reported to bind MYC, then the genes that bind MYC but lack the Ebox, and then the genes that bind MYC and contain an Ebox were included in the analysis.
In order to identify genes that bind the same transcription factors, we used ChIP-chip data [ 33].
The increased NRSF levels, unexpectedly, did not affect the genes that bind tightly to this transcription factor.
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We also performed an analysis of the target genes that bound FLAG-Nup98-HoxA9 or Crm1.
Hence, most reported lengths of the ribosomal genes actually report the length of the sequence between the genes that bound the ribosomal genes.
As shown for the effector genes, the non-effector class L2 genes that bound Pch, but not Ler, were much more abundant than those that bound both (Fig. 5 and Table 2).
The homeobox is a highly conserved DNA sequence (homeodomain) within genes that binds to DNA in a sequence-specific manner [ 81] often at the promoter region of their target gene to affect transcription in the developing embryo.
The zinc-finger transcription factor early growth response factor-1 (Egr-1) belongs to the family of immediate-early genes that binds to GC-rich sequences in the promoter region of target genes involved in the development of atherosclerosis [25 27].
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