more than 50 possible longevity-associated variants in genes, some of which were unexpected and had not been seen before.
HIF-1 regulates a wide variety of genes, some of which are closely associated with tissue fibrosis.
DG neurons uniquely upregulated many genes, some of which are important for neuronal survival (e.g., Atf3, Inhba, Bdnf, Gadd45b 55.
Using this new evolution-based approach, the scientists have discovered many kinds of genes, some of which may prove a boon to the biotechnology industry.
Mutations in wntD cause susceptibility to Listeria monocytogenes infection, apparently through the derepression of Toll-Dorsal target genes, some of which are deleterious to survival.
"Long after speciation, even nonsister species can actually exchange genes, some of which are useful," James Mallet, an evolutionary biologist at Harvard, told me.
The most virulent, Candida albicans, possesses at least nine SAP genes, some of which are specifically expressed from cells with morphologies associated with virulence.
Temporal kinetics of transcriptional activation after hepatectomy reveals a pattern of early induction for several genes, some of them controlled by the CREB/CREM transcription factors.
We identified modules of highly coexpressed genes, some of which are restricted to a single lineage but most of which are expressed at variable levels across multiple lineages.
We explore risk loci where TWAS accurately prioritizes the likely causal gene, as well as loci where TWAS prioritizes multiple genes, some of which are unlikely to be causal, because they share the same variants as eQTLs.
The research identifies acquired mutations in eight high-risk genes, some of which are associated with as much as 30- to 50-fold greater risk of developing the disease.
