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The low mutation frequency observed for TP53 on sample tissues where other genes show higher values confirms that genes may be differently affected by background genetic noise.
Preliminary evidence supporting the hypothesis that duplicated genes show higher levels of intraspecific variation was obtained in a study with yeast and fruit flies [13].
However, these "secondary" functions seem to be less tightly regulated, as is reflected by the lower percentage of experiments in which these genes show higher expression in ESCs and iPSCs compared to fibroblasts, among the top 1,000 changes (see Figure S7).
Accordingly, ESR genes show higher trans effects.
Conversely, brain-selective genes show higher similarities in terms of disease classes that they can predict.
Cancer and COSMIC genes show higher clustering coefficient than OMIM and non-cancer genes.
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Examining mRNA from defined neurons, we unexpectedly show extremely common unbalanced expression of cognate 3' UTR and CDS sequences; many genes show high 3' UTR relative to CDS, others show high CDS to 3' UTR.
These OR genes show high similarity to known lepidopteran sex pheromone receptor subfamily genes [24] [25].
These genes show high expression levels in the embryos at early stages, especially at 0.75 and 2 hpf (Figure S6).
Both genes show high levels of silent nucleotide divergence across the Drosophila genus.
Cellulase genes show high turnover with significant birth and death rates.
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