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Considering that our current subset of Xrn1-activated genes represents a stringent selection of Xrn1-dependent events, our analysis might miss transcripts affected by Xrn1 depletion (false negatives).
RNA interference (RNAi) therapy, which silences expression of specific target genes, represents a promising approach for treating viral infections in mammalian hosts.
The identification of disease-relevant genes represents a challenge in microarray-based disease diagnosis where the sample size is often limited.
Targeting MLL1 enzymatic activity to regulate expression level of MLL-dependent genes represents a therapeutic strategy for acute leukemia harboring MLL fusion proteins.
The intragenic heterogeneity encountered in many dominant disease-causing genes represents a significant challenge with respect to development of economically viable therapeutics.
Identification of the genes represents a vital step toward developing compounds that can be used in targeted, individualized treatment of severe periodontitis, before loss of teeth and supportive bone occurs.
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MalR activation of the mal genes represents an example of a LuxR homolog that is not a receptor for an AHL quorum-sensing signal.
Recurrent MET fusion genes represent a drug target in pediatric glioblastoma.
International Cancer Genome Consortium PedBrain Tumor, P. Recurrent MET fusion genes represent a drug target in pediatric glioblastoma.
Thus, MAT genes represent a powerful tool to delimit cryptic species in the genus Neofusicoccum.
Currently, more than 250 genes representing a wide variety of functional roles have been shown to be responsible for the disease phenotypes.
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