Exact(2)
That is, a strong mutation often has no apparent phenotypic effect only if multiple other genes remain functional.
A reciprocal silencing of homoeologs in different organs was reported such that both genes remain functional in different parts of the plant, suggesting subfunctionalization.
Similar(57)
This observation is consistent with the fact that products of retrotransposition, in the absence of a nearby promoter, are, in essence, pseudogenes as soon as they are inserted in the genome ("dead-on-arrival" [ 36]), and begin accumulating mutations faster than duplicated genes which remain functional for a period of time after duplication.
San Mauro et al. [ 29] also indicated that the evidence for this model in the form of duplicated genes that either remain functional or have become pseudogenes in the process of being eliminated is rather limited.
Lens transplanting experiments show that after thousands of years of evolution in caves, most eye genes remain perfectly functional.
Furthermore, gene modules need not be contiguous or clustered to remain functional.
Guns remain functional for centuries.
Apple's services, including iMessage, remain functional.
Collin and Cipriani (2003) [ 32] go on to suggest that unused genes remain in a functional state in genome for ~6 my but are almost certain to lose their function at about 10 my.
The B*38 gene may have remained functional, since the truncation did not affect enhancer sequences.
Although mice with targeted depletion of the Anxa6 gene remain viable, functional redundancies within the annexin family have been proposed to compensate for the loss of Anxa6 function.
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