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Microarray analysis of primary human CD34+ cells shows that HOXA9 dysregulates genes recognized by 659 probe sets compared to only 203 for NUP98-HOXA9/N51S (Fig. 11).
To maximize number of genes recognized by DAVID, we split gene complexes and families into their component genes.
The BeadArray used in this study contained 23,584 probes, representing 20,692 genes recognized by RefSeq [ 38].
The probe sets used and the genes recognized by these probe sets can be found at the 'CYPedia' home page.
DNA hypermethylation in inflamed tissues is also strongly targeted to genes recognized by the Polycomb complex [ 38].
Overall, our results indicate that both the host genes that carry the same putative miRNAs and the target genes recognized by the same miRNAs, are evolutionarily conserved.
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Importantly, our analysis revealed that the distinctive sequence features of the SLC6A3 gene recognized by an array of regulatory mechanisms are evolutionally recent.
Another type of defense response occurs after attack by virulent pathogens that do not have an avr-gene recognized by the plant.
A T/C SNP in intron 1 and exon 2 boundary of estrogen receptor (ER) α gene recognized by PvuII enzyme has been associated with several female pathologies like breast cancer, osteoporosis, endometriosis and fibroids in various ethnic groups.
Allelic variants of the VDR gene, recognized by ApaI (allele A/a C-A), BsmI (allele B/b G-A), FokI (allele F/f C-T), and TaqI (allele T/t T-C) restriction endonucleases, have been associated with bone mineral density (BMD) in many studies as well as with bone loss in elderly subjects.
In this way, the interplay between the mechanisms of hormone action and the organ systems physiology, and the consequences of hormone gene regulation is easily recognized by students.
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