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While powerful for understanding general evolutionary trends, such studies may overlook differences in evolutionary mode between different genes or different introns within the same species.
It is thus likely that the differences in the genetic background of these populations mean that other genes or different variants are underlying the disease.
These multiple mod and resc factors could theoretically be encoded by different copies (i.e., variants) of same mod/resc genes or different mod and resc genes within the same wPip genome15, 17.
If there is redundancy, overlap, or confusion caused by use of the same name for different genes or different names for the same gene, the first published gene name will generally be retained and the CSGNL will work with the authors of publications to identify a new gene name and gene symbol for the subsequently reported gene(s) or loci.
In all bilaterian animals that have been studied, multiple Hox genes are found in their genomes and, over the course of development, different regions along the primary body axis come to express different Hox genes or different combinations of Hox genes.
It describes the biological complexity whereby apparently similar inheritable characters result from different genes or different genetic mechanisms.
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Furthermore, the biological system gains additional control of gene expression by modifying the co-regulators via different cell signalling pathways, which allow the regulators to target different subsets of co-regulators at different genes or in different cell types.
These differences could represent different copies of the same gene or different alleles within the population (UTRs were not available in most cases to determine which).
Therefore, it is an open question whether PpCSP1 and Lin28 have evolved from a common gene or different genes of the last common ancestor.
It was thus not clear whether in the case of a single-gene signature the same gene or different genes were selected in each fold of cross-validation.
High quality SNP-containing reads were filtered out, with unique match to the RefSeq gene (or different transcripts of the same Entrez gene).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com