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Finally, Sirt3 showed the highest degree of genetic variation among 24 candidate genes of aging in a population of healthy seniors aged 85 years and above, who had never been diagnosed with cancer, diabetes, cardiovascular, pulmonary or Alzheimer disease [ 11].
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The identification from the 1980s onwards of many C. elegans mutants with altered aging rate [ 1] led to optimism that discovery of gene products of aging control genes would reveal the mechanisms of aging in this organism.
Our TERT-based gene therapy of aging also improved several molecular markers of aging.
We treated genes of age 0 as species specific.
The large overlap between aging genes and genes of age-related major diseases makes drugs that aid healthy aging promising candidates for the prevention and treatment of age-related diseases, such as cancer, atherosclerosis, diabetes and neurodegenerative disorders.
With the advent of technology allowing for genome-wide surveys of gene expression, studies of aging have become feasible at the molecular level.
However, it is presently unclear how these epigenetic changes affect the gene expression patterns of aging human tissues.
Using the latter strategy, we have measured 21 cardiovascular-related biomarkers in an extended multigenerational pedigree, the CARRIAGE family (Carolinas Region Interaction of Aging, Genes, and Environment).
The high connectivity of aging genes was used by Tacutu et al.
Co-expressed transcription factors were investigated, identifying C/ebp genes as candidate regulators of aging.
Additionally, this model identifies a novel set of aging genes previously uncharacterized in the hippocampus.
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