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To understand which DNA changes are important, the genes must be put into another species.
Also, specific genes must be identified for different strains of diseases.
That means multiple genes must be disabled or the trait will not be changed.
If genes determine who gets Alzheimer's at older ages, Dr. Pedersen says, "those genes must be very common, have small effects and probably interact with the environment".
Many biotech companies, big and small, argue that genes must be patentable to allow firms to recoup their investment in identifying them.
It has been found that expression of genes encoding plant enzymes and selected endogenous genes must be delicately adjusted in microbes, otherwise isoprenoid production is negatively affected.
Genes must be stably integrated into bacterial chromosomes for complementation of gene deletion mutants in animal infection experiments or to express antigens in vaccine strains.
He said the method should be useful in any kind of genetic engineering where genes must be inserted at a specific site, and in any genome project where the function of an unknown gene could be ascertained by disrupting it.
The evolutionary theory of aging, which predicts that many genes must be involved in determining life span, recently collapsed when researchers found that the lifetimes of laboratory organisms can be tripled or better by changing a single gene.
Each cell must avoid being committed to any particular fate for the time being, so all its master regulator genes must be repressed by tight winding of the spools that hold their DNA.
The regulated genes must be regarded as having the potential to diagnose acute myocardial infarction rather than representing a ready-made diagnostic panel.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com