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The quest to find the remaining AD genes led us to undertake a large genomic screen using over 466 families (730 affected sibpairs) in late-onset AD.
Additional file 1: Figure S2 reveals that the genes coding the enzymes (EC: 1.14.18.1; EC: 4.1.1.28; and EC: 2.1.1.6) were significantly up-regulated, and these up-regulated genes led us to investigate why red pigments did not appear during shake cultivation.
The high mutation rates achieved when targeting single genes led us to investigate whether we could mutate two genes simultaneously.
Ultimately, the conflicts present within these genes led us to reconstruct the unique central rooted ring reported here.
The motifs discovered in the corresponding genes led us to propose several factors and co-factors potentially acting in trans, along with putative cis-regulatory modules.
This localization of adaptive selection in Adam genes led us to hypothesize an important role in sperm-egg interactions with positive selection possibly driven by sexual selection.
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Furthermore, the conserved nature of most of these gene products has led us to extend our hypothesis - that they also may be requisite virulence effectors in other Brucella susceptible hosts.
Whether our genes lead us to war or peace depends on the particular social environment in which we live.
The phenotype of the BR- and ABA-deficient mutant and the lack of a significant flowering phenotype in the transgenic lines that over-express the DWF4 and NCED3 genes, leads us to a conclusion that these hormonal pathways are necessary for proper timing of the floral transition, but are themselves insufficient to significantly modify the transition time.
The in-depth interrogation of CAMTA1 dependent genes lead us to hypothesis a biological network involved in drought stress guarded by CAMTA 1.
The limited degree of overlap between these two sets of induced genes leads us to conclude that these two cellular stress responses are mechanistically distinct, though some degree of overlap cannot be excluded.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com