Exact(24)
Put simply it means that although I have 64 faulty genes, it appears that I have another copy of each which is working correctly.
Looking further into the functions of the selected genes it appears that, in their majority, they participate in metabolic processes.
Based on our studies with these four genes, it appears that despite an overarching shared regulation, the finer workings of the mechanism of activation remain varied.
Since particular species, or closely related taxa, often possess exclusive sets of paralogous genes, it appears that class I lineages have undergone repeated, independent expansion and diversification events over the course of vertebrate evolution.
For these genes, it appears that the driving force of regulatory control is solely constituted by the superhelical DNA constraining capability of HU; effectively, these genes are not found in the reported supercoiling regulons [72], [73].
Since the cardioprotective abilities of resveratrol are intimately linked to the regulation of genes, it appears to be important to understand how resveratrol-mediated cardiac gene expression is controlled at the level of transcriptional regulation where transcription factors are associated with their regulatory DNA elements.
Similar(36)
From inspection of the cell cycle time courses for individual genes, it appeared that many genes maintained moderate steady-state mRNA levels throughout the cycle, reflecting shallower cyclic mRNA patterns, while relatively fewer genes (e.g. rhoptry genes discussed below) had profiles with large amplitudes that declined to the very low levels of expression.
Upon closer inspection of these five genes, it appeared Tiling Assembly correctly identified genes within the same location; however, there were differences in how the genes were identified.
As an intron was found at this same position in PMP22, EMP-1 and EMP-3 genes, it appeared likely that we had identified the first coding exon of the human BCMP1 gene.
While a number of existing QTLs are near this same locus and associated with the hemolytic complement component C5 Hc gene, it appears that the classic variation in this gene, a premature stop codon, does not account for the variation seen, as only B6 mice show PECAM-independent TGP, while other Hc-positive strains do not.
Thus, on the basis that the TSP-5 locus arose through duplication of an ancestral TSP-4-like gene, it appears that the encoded protein retained TSP-4-like character in fish and has evolved distinct and novel features in tetrapods.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com