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The correlation between evolutionary rate and essentiality of genes is weak [ 34], where gene essentiality tends to be associated with adaptive evolution in protein sequence.
The elevated nucleotide diversity at both synonymous and nonsynonymous sites in the Imd pathway genes could be consistent with adaptive maintenance of polymorphism, or alternatively could indicate that purifying selection on these genes is weak relative to control genes, allowing deleterious nonsynonymous mutations to persist in the population as effectively neutral polymorphisms.
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Evolutionary theory [ 7, 11] has shown that genes with strictly maternal expression evolve differently than constitutively expressed genes, because selection on sex-specific genes is weaker [ 11- 14].
The association of this MITE with the SIX genes is weaker than the mimp association with the SIX gene promoters, because it is not present downstream of all the SIX genes on the pathogenicity chromosome.
Likewise, for the duplication, transcriptional compensation of ubiquitously expressed genes is weaker than that of tissue-specific genes, in a reversal of the pattern observed on figure 3 B in Stenberg et al. (2009).
Although in Australia continent the role of insertion/deletion mutations in BRCA1 and BRCA2 genes is weaker, some single nucleotide polymorphisms (SNP) showed significant association with BC risk which was discussed in polymorphism section.
Notably, the signal intensity for stable nucleosomes on the TATA-containing genes is weaker than on the TATA-free genes, confirming that most of the TATA-containing genes are strongly expressed and tend to be regulated by chromatin architecture [ 16, 33].
However, because the correlation between M/F and d N /d S for male-biased genes is weaker in the obscura lineage than the melanogaster lineage (table 1), it may be that the limited sample size of Metta et al. (2006) prevented the detection of a difference in molecular evolutionary rate among groups of genes.
Associations between SNPs in the other investigated cell growth/differentiation and apoptosis pathway genes were weak and less promising.
In the present study LD within genes was weak for BLZ1 and HvGAMYB but strong for the other two genes.
The low coverage of L0 genes (<50%) (Additional File 1, Table S4), indicated that the functional relationship between L0 genes was weak.
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