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In mutant cells, chromatin accessibility of periodic genes, including TORC1-responsive genes, is relatively static, concomitant with severely attenuated gene expression.
Microarray analysis showed that only 14 other transcripts (of 11 000 surveyed) increased in abundance by two-fold or more in high-folate fruit, demonstrating that the induction of folate pathway genes is relatively specific.
Hence, the number of IR64- and Apo-favoring genes is relatively equal.
Pinpointing the location of the genes for traits controlled by single genes is relatively straightforward.
This may be partly explained by the fact that these proteins and genes are well referenced and so finding the links associated with these genes is relatively easy.
However, our results indicate that drug-induced demethylation of specific genes is relatively inefficient when compared to the entire genome and to DNMT-deficient cells.
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However, these changes in expressions for all of the genes were relatively small (Supplemental Tables 3 and 4).
But the methylation levels of the CpG sites or genes were relatively stable as the AMD increased, (Supplementary Fig. S2d-e).
Further analysis showed that the core genes of the MHC-I antigen presentation pathway were strongly correlated across the cohort and that the expression of several antigen presentation genes was relatively high in tumors from patients with clinical benefit.
The two genes are relatively conserved but they are very distinct in their 3′ ends, enabling the design of specific primers.
Although less efficient than chemicals in creating mutants, the virus has a key advantage: The disturbed genes are relatively easy to find via standard genetic techniques.
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